Product overview Description Anti-IL10RA rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human IL10RA
Reactivity Human
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol IL10RA
Full name Interleukin-10 receptor subunit alpha
Synonyms CD210, IL10R, CD210a, CDW210A, HIL-10R, IL-10R1
Swissprot Q13651
Target Background The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.