Anti-ADSL antibody

Anti-ADSL antibody

Cat. No.     JC121520        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ADSL rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Fusion protein of human ADSL
Reactivity                 Human, Mouse
Content                     0.54 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-ADSL antibody
Target information
Symbol                 ADSL
Full name                 adenylosuccinate lyase
Synonyms    ASL; AMPS; ASASE
Swissprot    P30566

Target Background
The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene.

Anti-ADSL antibody
Applications
Western blotting
Predicted band size:55 kDa
Positive control:A549 and HEPG2 cell lysates 
Recommended dilution: 200-1000