Product overview
Description Anti-ACVR1C rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human ACVR1C
Reactivity Human, Mouse, Rat
Content 0.2 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol ACVR1C
Full name activin A receptor, type IC
Synonyms ALK7; ACVRLK7
Swissprot Q8NER5
Target Background
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).