整合素抗体套装，Integrin Antibody Samp

整合素抗体套装，Integrin Antibody Sampler Kit
整合素抗体套装含以下抗体
Integrin α5 Antibody 40 µl
Integrin αV Antibody 40 µl
Integrin β4 Antibody 40 µl
Integrin α4 (D2E1) XP® Rabbit mAb 40 µl
Integrin β1 (D2E5) Rabbit mAb 40 µl
Integrin β3 (D7X3P) XP® Rabbit mAb 40 µl
Integrin beta-5 (D24A5) Rabbit mAb 40 µl
Anti-rabbit IgG, HRP-linked Antibody 100µl


All antibodies in the Integrin Antibody Sampler Kit detect endogenous levels of their target α and β integrin subunits of the integrin dimer. None of the antibodies provided detect intact dimers or their activational state.
The Integrin Antibody Sampler Kit provides an economical means to screen samples for α and β subunits of integrin molecules. The kit includes enough primary and secondary antibody to perform four Western blot experiments with each antibody.
文献

Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2).

1. Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.

2. Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.

3. van der Flier, A. and Sonnenberg, A. (2001) Cell Tissue Res 305, 285-98.