PD-L1 (Extracellular Domain Specific) (D8T4X) Rabbit mAb
库存:
大量
供应商:
科敏商城
CAS号:
IF , F ,
规格:
100 ul (200 assays)
品牌:CST,产品名称:PD-L1 (Extracellular Domain Specific) (D8T4X) Rabbit mAb #86744 英文名称:PD-L1 (Extracellular Domain Specific) (D8T4X) Rabbit mAb Product name:PD-L1 (Extracellular Domain Specific) (D8T4X) Rabbit mAb #86744 Isotype:Rabbit IgG Sensitivity:Endogenous Reactivity:H Applications:IF , F , Purification: Monoclonal antibody is produced by immunizing animals with mammalian cells expressing full length PD-L1 protein. Background: Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).
PD-L1 (Extracellular Domain Specific) (D8T4X) Rabbit mAb recognizes endogenous levels of total PD-L1 protein.
Species Reactivity:
Human
Application
Dilutions
Immunofluorescence (Immunocytochemistry)
1:200
Flow Cytometry
1:100
Storage:
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.