品牌:CST,产品名称:PD-L1 (E1L3N) XP Rabbit mAb (Biotinylated) #15118
英文名称:PD-L1 (E1L3N®) XP® Rabbit mAb (Biotinylated)
Product name:PD-L1 (E1L3N®) XP® Rabbit mAb (Biotinylated) #15118
Applications:WB ,
Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PD-L1 protein.
Background: Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).
Entrez-Gene Id
29126
Swiss-Prot Acc.
Q9NZQ7
Specificity / Sensitivity:
PD-L1 (E1L3N®) XP® Rabbit mAb (Biotinylated) recognizes endogenous levels of total PD-L1 protein.
Species Reactivity:
Human
Application |
Dilutions |
Western Blotting |
1:1000 |
Storage:
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Product Description:
This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated PD-L1 (E1L3N®) XP® Rabbit mAb #13684.