品牌:CST,产品名称:NRBF-2 (D8G1) Rabbit mAb #8633
英文名称:NRBF-2 (D8G1) Rabbit mAb
Product name:NRBF-2 (D8G1) Rabbit mAb #8633
Source:Rabbit
Sensitivity:Endogenous
MW(kDa):40
Applications:WB , IP ,
Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NRBF-2 protein.
Background: Nuclear Receptor Binding Factor-2 (NRBF-2), also referred to as Comodulator of PPAR and RXRα-2 (COPR-2), has been shown to interact with the AF-2 region of several nuclear hormone receptors with varying affinities such as PPARα, RARα, RARγ, and RXRα (1,2). NRBF-2 contains a LLYLL motif, which matches the LXXLL NR box consensus and is required for functional NRBF-2/nuclear receptor complex formation and repression of receptor function. NRBF-2 also contains a unique autonomous activation domain and, thus, does not completely abrogate nuclear receptor function, suggesting that NRBF-2 might serve as a molecular rheostat to fine-tune the transcriptional activity of liganded nuclear receptors (1,2).
Entrez-Gene Id
29982
Swiss-Prot Acc.
Q96F24
Specificity / Sensitivity:
NRBF-2 (D8G1) Rabbit mAb recognizes endogenous levels of total NRBF-2 protein. Based upon sequence alignment, this antibody is predicted to cross-react with NRBF-1/COPR1.
Species Reactivity:
Human, Mouse, Rat, Monkey
Species predicted to react based on 100% sequence homology:
Hamster, Bovine, Dog, Horse
Application |
Dilutions |
Western Blotting |
1:1000 |
Immunoprecipitation |
1:100 |
Storage:
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.