IL-1α (D4F3S) Rabbit mAb (Mouse Specific) (PE Conjugate)
库存:
大量
供应商:
科敏商城
CAS号:
F ,
规格:
100 ul (50 tests)
品牌:CST,产品名称:IL-1α (D4F3S) Rabbit mAb (Mouse Specific) (PE Conjugate) #53957 英文名称:IL-1α (D4F3S) Rabbit mAb (Mouse Specific) (PE Conjugate) Product name:IL-1α (D4F3S) Rabbit mAb (Mouse Specific) (PE Conjugate) #53957 Applications:F , Purification: Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of mouse IL-1α protein. Background: Interleukin 1 alpha (IL-1a) belongs to the IL-1 family of cytokines with 11 members including IL-1b. IL-1a is expressed in many cell types of both hematopoietic and non-hematopoietic origins under steady state, and its expression can be increased in response to appropriate stimuli (1,2). Like IL-1b, IL-1a is also synthesized as a precursor (pro-IL-1a) and can be cleaved into smaller mature forms. However, both pro-IL-1a and the cleaved form of IL-1a are biologically active and can activate the signaling pathway through the membrane receptor IL-1R1. IL-1a is active both as a secreted form and as a membrane-bound form. Due to such characteristics, passive leakage of IL-1a from dying cells can activate inflammation, leading some researchers to consider IL-1a as a key “alarmin in the cell” that alerts the host to damage or injury (3,4). In addition, IL-1a can also enter the nucleus to modulate transcription (5,6).
IL-1α (D4F3S) Rabbit mAb (Mouse Specific) (PE Conjugate) recognizes endogenous levels of total IL-1α protein.
Species Reactivity:
Mouse
Application
Dilutions
Flow Cytometry
1:50
Storage:
Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Product Description:
This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometric analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated IL-1α (D4F3S) Rabbit mAb (Mouse Specific) #50794.