品牌:CST,产品名称:SORL1 (D8D4G) Rabbit mAb #79322 英文名称:SORL1 (D8D4G) Rabbit mAb Product name:SORL1 (D8D4G) Rabbit mAb #79322 Source:Rabbit Sensitivity:Endogenous MW(kDa):18 Applications:WB , IF , Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu267 of human SORL1 protein. Background: SORL1, also called SorLA, is a 250 kDa type-1 membrane protein found in neurons of the central and peripheral nervous system (1). SORL1 is related to the yeast transporter Vps10p (2). While its exact function is unknown, because it shuttles between the Golgi apparatus and endolysosomal compartments, and given its structural similarity with Vps10p, it has been suggested that SORL1 acts in intracellular trafficking (3). Interestingly, SORL1 expression has been shown to be decreased in the brain of patients with Alzheimer's disease (4), and research studies have demonstrated a role for SORL1 as a neuronal sorting receptor that binds APP and regulates its trafficking and proteolytic processing, thus regulating the production of amyloid-beta peptides (5).
SORL1 (D8D4G) Rabbit mAb recognizes endogenous levels of total SORL1 protein.
Species Reactivity:
Human, Mouse
Application
Dilutions
Western Blotting
1:1000
Immunofluorescence (Frozen)
1:800
Storage:
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.