品牌:CST,产品名称:Coronin 1A (D6K5B) XP Rabbit mAb #92904 英文名称:Coronin 1A (D6K5B) XP® Rabbit mAb Product name:Coronin 1A (D6K5B) XP® Rabbit mAb #92904 Isotype:Rabbit IgG Sensitivity:Endogenous MW(kDa):60 Reactivity:H,M Applications:WB , IHC , F , Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val200 of human coronin 1A protein. Background: The coronin family of actin-binding proteins regulates a variety of cellular functions, including migration, phagocytosis, and cytokinesis. Coronin 1A is highly expressed in lymphocytes, and is required for appropriate immune regulation in mice and humans. Researchers are investigating coronin 1A as a potential therapeutic target for autoimmune diseases and lymphoid cancers (1,2). Coronin 1A affects bone resorption through its regulation of lysosome fusion and secretion of cathepsin K in osteoclasts (3). In the nervous system, coronin 1A has been shown to regulate GPCR signaling and neurite outgrowth (4,5).
Coronin 1A (D6K5B) XP® Rabbit mAb recognizes endogenous levels of total coronin 1A protein. Based on the sequence of the immunogenic peptide, this antibody is not expected to cross-react with other coronin protein family members.
Species Reactivity:
Human, Mouse
Application
Dilutions
Western Blotting
1:1000
Immunohistochemistry (Paraffin)
1:200
Flow Cytometry
1:50
Storage:
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.