品牌:CST,产品名称:PhosphoPlus Cleaved PARP (Asp214) Antibody Duet #12061 英文名称:PhosphoPlus® Cleaved PARP (Asp214) Antibody Duet Product name:PhosphoPlus® Cleaved PARP (Asp214) Antibody Duet #12061 Isotype:Rabbit Sensitivity:Endogenous MW(kDa):116, 89 Background: PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2,3) and is one of the main cleavage targets of caspase-3 in vivo (4,5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) (2,4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6).
Cleaved PARP (Asp214) (D64E10) XP® Rabbit mAb 5625
100 µl
WB
IP
IHC
IF
F
H Mk
89
Rabbit IgG
PARP (46D11) Rabbit mAb 9532
100 µl
WB
IP
IF
H M R Mk
116, 89
Rabbit
Product Description:
PhosphoPlus® Duets from Cell Signaling Technology (CST) provide a means to assess protein activation status. Each Duet contains an activation-state and total protein antibody to your target of interest. These antibodies have been selected from CST's product offering based upon superior performance in specified applications.