品牌:CST,产品名称:CD163 (D6U1J) Rabbit mAb #93498 英文名称:CD163 (D6U1J) Rabbit mAb Product name:CD163 (D6U1J) Rabbit mAb #93498 Isotype:Rabbit IgG Sensitivity:Endogenous MW(kDa):160, 170 Reactivity:H Applications:WB , IHC , Purification: Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the human CD163 protein. Background: CD163 is a transmembrane scavenger receptor expressed on the macrophage surface. It has 9 B-type SRCR extracellular domains mediating serum haptoglobin clearing/endocytosis, pathogen binding and signal transduction, and calcium binding (1, 2). CD163 is used as a surface marker of M2 type macrophages, including M2 type tumor associated macrophages (TAMs), which facilitate cancer progression by secreting cytokines to promote angiogenesis, immunosuppression and metastasis (3). Inflammatory stimulation and stress signal can induce extracellular domain shedding of CD163 to generate soluble CD163 (sCD163). The increased sCD163 level in serum is associated with low-grade inflammation in disease conditions (4-7).
CD163 (D6U1J) Rabbit mAb recognizes endogenous levels of total CD163 protein.
Species Reactivity:
Human
Application
Dilutions
Western Blotting
1:1000
IHC-Leica® Bond™
1:400
Immunohistochemistry (Paraffin)
1:500
Storage:
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.