Product overview Description Anti-DDR2 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Synthetic peptide of human DDR2 Reactivity Human, Mouse Content 0.4 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol DDR2 Full name discoidin domain receptor tyrosine kinase 2 Synonyms TKT; MIG20a; NTRKR3; TYRO10 Swissprot Q16832
Target Background Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain.
Applications Immunohistochemistry Predicted cell location: Cytoplasm Positive control: Human thyroid cancer Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml260967(DDR2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)