Product overview Description Anti-GRIN2A rabbit polyclonal antibody Applications ELISA, IHC Immunogen Synthetic peptide of human GRIN2A Reactivity Human, Mouse, Rat Content 0.5 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol GRIN2A Full name glutamate receptor, ionotropic, N-methyl D-aspartate 2A Synonyms LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A Swissprot Q12879
Target Background This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.
Applications Immunohistochemistry Predicted cell location: Cell membrane Positive control: Human esophagus cancer Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml260672(GRIN2A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)