Anti-DNAJC8 antibody

Anti-DNAJC8 antibody

Cat. No.     JK263717      
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-DNAJC8 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human DNAJC8
Reactivity                 Human, Mouse, Rat
Content                     1.02 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification


Target information
Symbol                 DNAJC8
Full name                 DnaJ heat shock protein family (Hsp40) member C8
Synonyms    SPF31; HSPC331
Swissprot    O75937

Target Background
The DnaJ family is one of the largest of all chaperone families and has evolved with diverse cellular localization and functions. Presence of a J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are derived from Escherichia coli and are under the control of the htpR regulatory protein. DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. DnaJ proteins contain cysteine rich regions that are composed of zinc fingers, which form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJC8 (DnaJ (Hsp 40) homolog, subfamily C, member 8), also known as SPF31 or HSPC331, is a 253 amino acid protein that is suggested to have a potential role as a cochaperone in RNA processing-related processes.