Product overview Description Anti-API5 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Synthetic peptide of human API5
Reactivity Human
Content 0.1 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol API5
Full name apoptosis inhibitor 5
Synonyms AAC11; AAC-11
Swissprot Q9BZZ5
Target Background This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.