Anti-KRTAP11-1 antibody

Anti-KRTAP11-1 antibody

Cat. No.     JLC162863
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-KRTAP11-1 rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Synthetic peptide of human KRTAP11-1
Reactivity                 Human, Mouse
Content                     1.1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification



Target information
Symbol                 KRTAP11-1
Full name                 keratin associated protein 11-1
Synonyms    HACL1; HACL-1; KAP11.1
Swissprot    Q8IUC1

Target Background
Hair is a structure that is unique to mammals. It plays an important role in the retention of heat, as well as sexual dimorphism, attraction of mates and protection of skin. The major components of hair are å-keratins and keratin-associated proteins (KRTAPs or KAPs), each of which are encoded by multigene families. Hair keratins form an intermediate filament (IF) network, which is embedded in an interfilamentous matrix consisting of KRTAPs. KRTAPS comprise three major groups, which are essential for the formation of rigid and resistant hair shafts through disulfide bond cross-linking or hydrophobic interactions with keratins. These groups are designated high cysteine (HS), which includes subfamilies 1, 2, 3, 10, 12, 16, 29 and 31, ultrahigh cysteine, including subfamilies 4, 5, 9, 17, 28, 30, 32 and 33, and high glycine-tyrosine (HGT), which includes subfamilies 6, 7, 8, 19, 20 and 21. In addition, subfamilies 11, 13, 24-27, 29, 34 and 35 have high serine content but relative low cysteine content. After further phylogenetic studies, subfamilies 14 and 15 have been grouped with subfamily 13 and subfamily 22 was combined with subfamily 19.