abcam- Hela-DFO treated (0.5mM

Hela-DFO treated (0.5mM，24h)核裂解物(ab180880)

• 产品名称

  Hela-DFO treated (0.5mM，24h)核裂解物

• 常规说明

  We recommend aliquoting the extracts into single use fractions and then storing them at -80°C.

  The cells were treated for 24 hours with a 0.5mM solution of Deferoxamine (DFO). DFO is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). DFO stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of DFO inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.

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