Product overview
Description Anti-HIPK3 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human HIPK3
Reactivity Human, Rat
Content 0.36 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol HIPK3
Full name homeodomain interacting protein kinase 3
Synonyms PKY; YAK1; DYRK6; FIST3
Swissprot Q9H422
Target Background
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).