Product overview Description Anti-DSP rabbit polyclonal antibody Applications ELISA, IHC Immunogen Synthetic peptide of human DSP Reactivity Human, Mouse Content 1 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol DSP Full name desmoplakin Synonyms DP; DPI; DPII Swissprot P15924
Target Background Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Applications Immunohistochemistry Predicted cell location: Cytoplasm Positive control: Human tonsil Recommended dilution: 50-200 Predicted cell location: Cytoplasm Positive control: Human esophagus cancer Recommended dilution: 50-200
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ml260269(DSP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml260269(DSP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)