Product overview
Description Anti-BACE2 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human BACE2
Reactivity Human, Mouse, Rat
Content 0.2 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol BACE2
Full name beta-site APP-cleaving enzyme 2
Synonyms ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1
Swissprot Q9Y5Z0
Target Background
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.