Product overview Description Anti-F2 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human F2
Reactivity Human, Mouse, Rat
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol F2
Full name coagulation factor II (thrombin)
Synonyms PT; THPH1; RPRGL2
Swissprot P00734
Target Background Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.