Product overview
Description Anti-RBM38 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human RBM38
Reactivity Human, Mouse
Content 1.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol RBM38
Full name RNA binding motif protein 38
Synonyms RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
Swissprot Q9H0Z9
Target Background
RBM38 is a cell cycle protein found in the cytosol and the nucleus that exists as two alternatively spliced isoforms, 1 (RNPC1a) and 2 (RNPC1b), of 239 and 121 amino acids, respectively. Independent of p53 expression, RBM38 isoform 1 induces cell cycle arrest in G1 phase through maintaining transcript stability at the 3’-UTR of p21, a regulator of cell cycle progression at S phase. RBM38 is also an mRNA splicing factor that regulates the expression of FGFR2. RBM38 contains one RRM (RNA recognition motif) domain.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human esophagus cancer
Recommended dilution: 50-300 Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 50-300
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml262114(RBM38 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml262114(RBM38 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)