Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
适应物种:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
免疫原:
详见说明书
亚型:
IGg
形态:
粉末、液体、冻干粉
应用范围:
ICC=1:50-200 IF=1:50-200
浓度:
1mg/ml
保存条件:
-20 °C
规格:
100ul
FITC标记的G蛋白偶联受体1抗体
英文名称
Anti-GPR1/FITC
中文名称
FITC标记的G蛋白偶联受体1抗体
别 名
G protein coupled receptor 1; G-protein coupled receptor 1; GPR1; GPCR1/GPR1; GPR1_HUMAN.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
研究领域
神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用
ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
41kDa
细胞定位
细胞膜
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human GPR1
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. Gpr1 is required for yeast-to-hypha transition on various solid hypha-inducing media, and important for yeast cell morphology. It activates guanine nucleotide exchange on Gpa2 which stimulates cAMP synthesis by glucose. In Saccharomyces cerevisiae, Gpr1 is necessary for filamentous and invasive growth.
Function: Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.
Similarity: Belongs to the G-protein coupled receptor 1 family.
Database links: Entrez Gene: 2825 Human Entrez Gene: 25457 Rat Omim: 600239 Human SwissProt: P46091 Human SwissProt: P46090 Rat Unigene: 184907 Human Unigene: 81208 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.