关于NPC2:
Epididymal Secretory Protein E1 (NPC2) is a secreted protein that belongs to the NPC2 family. NPC2 is involved in the regulation of the lipid composition of sperm membranes during the maturation in the epididymis. NPC2 may regulate the transport of cholesterol through the late endosomal/lysosomal system. Defects in NPC2 are the cause of Niemann-Pick disease type C2, which affects the viscera and the central nervous system.