Product overview
Description Anti-KSR1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human KSR1
Reactivity Human, Mouse
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol KSR1
Full name kinase suppressor of ras 1
Synonyms KSR; RSU2
Swissprot Q8IVT5
Target Background
Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 has intrinsic kinase activity towards serine/threonine residues and is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase suppressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFß-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFß stimulation.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 50-200 Predicted cell location: Cytoplasm
Positive control: Human prostate cancer
Recommended dilution: 50-200
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml261844(KSR1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using ml261844(KSR1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)