Product overview
Description Anti-BGLAP rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human BGLAP
Reactivity Human
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol BGLAP
Full name bone gamma-carboxyglutamate (gla) protein
Synonyms OC; BGP; OCN
Swissprot P02818
Target Background
Bone gamma-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human brain
Recommended dilution: 50-200 Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 50-200
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using ml261481(BGLAP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml261481(BGLAP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)