Product overview
Description Anti-KCNQ4 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human KCNQ4
Reactivity Human, Mouse
Content 0.9 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol KCNQ4
Full name potassium voltage-gated channel, KQT-like subfamily, member 4
Synonyms DFNA2; KV7.4; DFNA2A
Swissprot P56696
Target Background
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.