Product overview
Description Anti-IL19 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human IL19
Reactivity Human
Content 0.9 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol IL19
Full name interleukin 19
Synonyms MDA1; NG.1; ZMDA1; IL-10C
Swissprot Q9UHD0
Target Background
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.