Product overview
Description Anti-NRG2 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human NRG2
Reactivity Human, Mouse, Rat
Content 1 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol NRG2
Full name neuregulin 2
Synonyms DON1; HRG2; NTAK
Swissprot O14511
Target Background
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described.
Applications
Immunohistochemistry
Predicted cell location: Secreted
Positive control: Human thyroid cancer
Recommended dilution: 50-300 Predicted cell location: Secreted
Positive control: Human ovarian cancer
Recommended dilution: 50-300
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml261359(NRG2 Antibody) at dilution 1/65, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using ml261359(NRG2 Antibody) at dilution 1/65, on the right is treated with synthetic peptide. (Original magnification: ×200)