Product overview Description Anti-UMPS rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human UMPS Reactivity Human, Mouse Content 0.6 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol UMPS Full name uridine monophosphate synthetase Synonyms OPRT Swissprot P11172
Target Background This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
Applications Immunohistochemistry Predicted cell location: Cytoplasm and Cell membrane Positive control: Human brain Recommended dilution: 30-150
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using ml224165(UMPS Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)