Product overview
Description Anti-PROM1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human PROM1
Reactivity Human, Mouse
Content 0.1 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol PROM1
Full name prominin 1
Synonyms RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061
Swissprot O43490
Target Background
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.