Product overview Description Anti-PDCD1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human PDCD1
Reactivity Human
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol PDCD1
Full name Programmed cell death 1
Synonyms PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l
Swissprot Q15116
Target Background This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.