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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial品名简称:
Recombinant Mouse Glp1r protein, partial货号:
CSB-EP009514MO1规格:
20μg价格:
1836LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 90% as determined by SDS-PAGE.内毒素:
Not test生物活性:
/基因名:
Glp1rUniprot No.:
O35659别名:
Short name: GLP-1 receptor Short name: GLP-1-R Short name: GLP-1R种属:
Mus musculus (Mouse)蛋白长度:
Partial来源:
E.coli分子量:
30.4 kDa表达区域:
22-145aa氨基酸序列:
GPRPQGTTVSLSETVQKWREYRRQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLSECEESKRGERNFPEEQLLSLY蛋白标签:
N-terminal 6xHis-SUMO-tagged产品提供形式:
Liquid or Lyophilized powder缓冲液:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
3-7 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.功能2:
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1)文献:
"Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene."Flamez D., van Breusegem A., Scrocchi L.A., Quartier E., Pipeleers D., Drucker D.J., Schuit F.Diabetes 47:646-652(1998)研究领域:
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文献和实验趁年轻,动起来:Nature 报道运动促进骨髓产生免疫细胞,但这种能力随年龄增长而消失
niche)。而 HSPCs 又负责生产血细胞系,包括免疫细胞 [3]。 在小鼠中,一些间质祖细胞产生一种被称为干细胞因子(stem cell factor,SCF)的信号分子,对 HSPCs 维持起到关键作用 [4]。这些细胞同时表达一种细胞表面蛋白,瘦素受体蛋白(Leptin Receptor,LepR)。这群 LepR+ 细胞在包括两种类型的血管、小动脉和血窦等完全不同的位置都有存留。然而,LepR+ 细胞群是由多种基质祖细胞组成的混合细胞群,哪些细胞是真正在维持 HSPC 微环境中起作用
would be the approx. 25 kDa Receptor-binding domain (RBD) of SARS-CoV-23 , which is the best-suited antigen for CoViD-19 immunity testing4. The most common reason is a simple steric hindrance that blocks access of antibodies from the specimen to the capture
导致Val66Met突变,降低BDNF分泌量,从而缩短ALS患者的生存期。利用ALS致病基因FUS R521C敲入小鼠模型进一步证明,BDNF半剂量不足会导致寿命缩短、运动功能障碍加速以及运动神经元死亡加剧。重要的是,使用激动性抗体激活BDNF受体TrkB,能够有效挽救ALS相关表型,在其他ALS小鼠模型中,TrkB激活抗体也显示出优于目前ALS治疗药物利鲁唑的治疗效果。该研究表明BDNF不足可能是ALS进展的关键促成因素,激活BDNF-TrkB通路代表了一种有前景的ALS治疗新策略
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