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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human Interleukin-17A protein (IL17A) (Active)
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
500μg/100μg/5μg
| 规格: | 500μg | 产品价格: | ¥15708.0 |
|---|---|---|---|
| 规格: | 100μg | 产品价格: | ¥6996.0 |
| 规格: | 5μg | 产品价格: | ¥852.0 |
纯度:
>95% as determined by SDS-PAGE.基因名:
IL17A,CTLA8,IL17Uniprot No.:
Q16552别名:
IL-17, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8种属:
Homo sapiens (Human)蛋白长度:
Full Length of Mature Protein来源:
E.Coli分子量:
15.1 kDa表达区域:
24-155aa氨基酸序列:
GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA蛋白标签:
Tag-Free产品提供形式:
Lyophilized powder缓冲液:
Lyophilized from a 0.2 µm filtered PBS, pH 7.4货期:
5-10 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能:
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.内毒素:
Less than 1.0 EU/µg as determined by LAL method.SDS-PAGE:
/LC-MS Image Description/Western Blot:
/Product types:
Active Protein & In Stock ProteinBiological_Activity:
Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of > 1.3 × 105 IU/mg.Research Areas:
ImmunologyReconstitution:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.Reference:
/Function:
Ligand for IL17RA and IL17RC风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验69、CD38 等活化指标,及 IFN-γ、IL-4、IL17A 等细胞因子,则需要设置同型对照,实现阴阳性细胞群的良好区分。 CD4 CD25 (2)在某些特殊情况下,如单核细胞被 PE/Cyanine 7、APC/Cyanine 7 等串联染料标记的抗体染色时,使用同型对照抗体是十分有必要的。单核细胞一般倾向于与 Cyanine7 等染料非特异性结合,使用同型对照抗体有助于获得理想结果。 (3)不清楚抗原表达情况的时候,一定要使用同型对照来界定阴性细胞群。 (4)胞内染色时
Cytotoxins Directed at Interleukin-4 Receptors as Therapy for Human Brain Tumors
Interleukin-4 (IL-4) is a pleiotropic immune regulatory cytokine that has been extensively studied in the last decade. Activated T-lymphocytes, mast cells, and basophils (1 –3 ) produce it. Consistent with the pleiotropic nature
又是代谢的锅,不治之症银屑病终于有盼头了!上交王宏林教授团队Immunity重磅报道
,对 K5. Pp6fl/fl 鼠皮损处样本进行 scRNAseq 检测,发现 IL17a 和 IL17f 主要由 γδT 细胞表达 (图 N)。图片来源:Immunity PP6 通过激活 C/EBP-β 促进银屑病角质形成细胞 arg1 转录接下来,作者研究发现 K5.Pp6fl/fl 鼠中受损皮肤中磷酸化 C/EBPβ(p-C/EBPβ,Thr-188) 增强。值得关注的是,K5.Pp6fl/fl 鼠皮损处 C/EBP-β 靶基因水平增加。同时,在 PP6 缺陷鼠的原代表皮细胞和 siRNA 敲除
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