Product overview Description Anti-ARL17 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human ARL17 Reactivity Human Content 0.5 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol ARL17 Full name ADP-ribosylation factor-like 17A/ADP-ribosylation factor-like 17B Synonyms ARF1P2; ARL17P1/ARL17; ARL17A Swissprot Q8IVW1
Target Background ARL17 (ADP-ribosylation factor-like protein 17), also known as ARF1P2 or ARL17P1, is a 177 amino acid member of the ARF protein family. In human, there are two genes which have been identified as ARL17A and ARL17B that code for identical proteins and colocalize at chromosomal position 17q21.31. ARL17 functions as an activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Localized to the Golgi apparatus, ARL17 may also be involved in the modulation of vesicle budding and uncoating within the Golgi. ARL17 is expressed as three isoforms produced by alternative splicing events.GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).
Applications Immunohistochemistry Predicted cell location: Cytoplasm and Nucleus Positive control: Human thyroid cancer Recommended dilution: 25-100 Predicted cell location: Cytoplasm and Nucleus Positive control: Human brain Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml223646(ARL17 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using ml223646(ARL17 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)