Product overview Description Anti-THAP4 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human THAP4 Reactivity Human, Mouse, Rat Content 0.3 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol THAP4 Full name THAP domain containing 4 Synonyms PP238; CGI-36 Swissprot Q8WY91
Target Background Human THAP4 is a 577 residue protein of unknown function that is proposed to bind DNA in a sequence specific manner similar to THAP1 and has been found to be upregulated in response to heat shock.THAP4 is expressed in a relatively uniform manner in a broad range of tissues and appears to be upregulated in lymphoma cells and highly expressed in heart cells13. The C-terminal domain of THAP4 (residues 415-577), designated here as cTHAP4, is evolutionarily conserved and is observed in all know THAP4 orthologues. Several single domain proteins lacking a THAP domain are found in plants and bacteria, and show significant levels of homology to cTHAP4. It appears that cTHAP4 belongs to a large class of proteins that have yet to be fully functionally characterized.
Applications Immunohistochemistry Predicted cell location: Nucleus and Cytoplasm Positive control: Human breast cancer Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using ml223317(THAP4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)