Product overview Description Anti-GRM4 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Synthetic peptide of human GRM4 Reactivity Human, Mouse, Rat Content 0.3 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol GRM4 Full name glutamate receptor, metabotropic 4 Synonyms mGlu4, GPRC1D, MGLUR4 Swissprot Q14833
Target Background L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
Applications Immunohistochemistry Predicted cell location: cytoplasm, Nucleus Positive control: Human breast cancer Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using ml260457(GRM4 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)