Product overview
Description Anti-GRIN2A rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human GRIN2A
Reactivity Human, Mouse, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol GRIN2A
Full name glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Synonyms LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A
Swissprot Q12879
Target Background
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.