Anti-FBLN5 antibody

Anti-FBLN5 antibody

Cat. No.     JLC160333
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-FBLN5 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human FBLN5
Reactivity                 Human, Mouse, Rat
Content                     1.24 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 FBLN5
Full name                 fibulin 5
Synonyms    EVEC, UP50, ADCL2, ARMD3, DANCE, ARCL1A, FIBL-5
Swissprot    Q9UBX5

Target Background
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).