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- MedChemExpress(MCE)
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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Prototimosaponin A III
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
136656-07-0
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 1 mg | 产品价格： | ￥304.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥700.0 |
| 规格： | 10 mg | 产品价格： | ￥1050.0 |
| 规格： | 25 mg | 产品价格： | ￥1785.0 |
| 规格： | 50 mg | 产品价格： | ￥2680.0 |
| 规格： | 100 mg | 产品价格： | ￥4020.0 |
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Timosaponin BII
CAS No. : 136656-07-0
MCE 国际站：Timosaponin BII
产品活性：Timosaponin BII (Prototimosaponin A III) 是在知母根茎中发现的一种甾体皂苷。Timosaponin BII 具有神经保护、抗炎和抗氧化活性。
研究领域：Neuronal Signaling
作用靶点：Amyloid-β
In Vitro: Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells.
In Vivo: Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time.
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文献和实验。直播者3年收获，分根繁殖者2年收获。趁鲜剥去外皮，用硫磺熏3-4小时，切片晒干或烘干为光知母，也叫知母肉。每公顷可收干货3t。 根茎含知母皂甙(Timosaponin)。味苦，性寒。有滋阴、降火、润燥功能。用于热病烦渴、肺热咳嗽、骨蒸潮热、消褐、肠燥便秘。
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