- ￥900 - 5700
- MedChemExpress(MCE)
- 美国
- HY-112430
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
259674-19-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥2550.0 |
| 规格： | 50 mg | 产品价格： | ￥3800.0 |
| 规格： | 100 mg | 产品价格： | ￥5700.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
TRPM8 antagonist 2
CAS No. : 259674-19-6
MCE 国际站：TRPM8 antagonist 2
产品活性：TRPM8 antagonist 2 是一种有效的，选择性的 TRPM8 拮抗剂，IC50 值为 0.2 nM，可用于研究神经性疼痛综合症。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：TRP Channel
In Vitro: TRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. TRPM8 antagonist 2 potently inhibits menthol-induced increase in intracellular Ca2+ levels in Ca2+ fluorimetric assays in HEK293 cells stably expressing the rat isoform of TRPM8 channels (IC50, 40 nM).
In Vivo: TRPM8 antagonist 2 (1, 10, and 30 mg/kg, s.c.) shows a marked, dose-dependent antinociceptive activity, and inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg. In addition, TRPM8 antagonist 2 (0.1 and 1 μg, s.c.) attenuates Oxaliplatin (OXP)-induced cold allodynia in mice.
相关产品：Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Peptidomimetic Library | Mechanoreceptors Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Ion Channel Compound Library | Rosiglitazone | Capsaicin | GsMTx4 | EIPA | Probenecid | Diphenyleneiodonium chloride | 2-Aminoethyl diphenylborinate | Amiloride hydrochloride | GSK1016790A | Capsazepine | HC-067047 | HC-030031 | ML-SA1 | GSK2193874 | Adenosine 5′-diphosphoribose sodium | AMG9810 | GSK205 | SKF-96365 hydrochloride | (-)-Menthol | Caffeic acid | ML-SI1 | BI-749327 | GSK2798745 | Pregnenolone | ML-SA5 | N-(p-amylcinnamoyl) Anthranilic Acid | A-967079 | MK6-83 | Pico145
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
