Product overview Description Anti-TLE1 rabbit polyclonal antibody Applications ELISA, WB, IHC Immunogen Fusion protein of human TLE1 Reactivity Human, Mouse Content 0.54 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol TLE1 Full name transducin like enhancer of split 1 Synonyms ESG; ESG1; GRG1 Swissprot Q04724
Target Background Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.