Product overview Description Anti-CHRD rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human CHRD Reactivity Human, Mouse, Rat Content 0.8 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol CHRD Full name chordin Synonyms Swissprot Q9H2X0
Target Background This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined.