Product overview Description Anti-SOCS6 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human SOCS6 Reactivity Human, Mouse Content 0.4 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol SOCS6 Full name suppressor of cytokine signaling 6 Synonyms CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060 Swissprot O14544
Target Background The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
Applications Immunohistochemistry Predicted cell location: Cytoplasm Positive control: Human colon cancer Recommended dilution: 50-200 Predicted cell location: Cytoplasm Positive control: Human gastric cancer Recommended dilution: 50-200
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ml221244(SOCS6 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ml221244(SOCS6 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)