Product overview Description Anti-RAMP3 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human RAMP3 Reactivity Human, Mouse, Rat Content 0.2 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol RAMP3 Full name receptor (G protein-coupled) activity modifying protein 3 Synonyms Swissprot O60896
Target Background The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
Applications Immunohistochemistry Predicted cell location: Cytoplasm Positive control: Human ovarian cancer Recommended dilution: 50-200 Predicted cell location: Cytoplasm Positive control: Human thyroid cancer Recommended dilution: 50-200
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using ml221149(RAMP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml221149(RAMP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)