Product overview Description Anti-ATIC rabbit polyclonal antibody Applications ELISA, WB Immunogen Fusion protein of human ATIC Reactivity Human, Mouse, Rat Content 0.2 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol ATIC Full name 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Synonyms PURH; AICAR; AICARFT; IMPCHASE; HEL-S-70p Swissprot P31939
Target Background This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.