Product overview
Description Anti-PPP1R12A rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Fusion protein of human PPP1R12A
Reactivity Human, Mouse, Rat
Content 0.1 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol PPP1R12A
Full name protein phosphatase 1, regulatory subunit 12A
Synonyms MBS; M130; MYPT1
Swissprot O14974
Target Background
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC.