浓 度 1mg/1ml 规 格 0.2ml/200μg 抗体来源 Rabbit 克隆类型 polyclonal 交叉反应 Human, Mouse 产品类型 一抗 研究领域 神经生物学 信号转导 细胞骨架 细胞外基质 Alzheimer's 蛋白分子量 predicted molecular weight: 79kDa 性 状 Lyophilized or Liquid 免 疫 原 KLH conjugated synthetic peptide derived from human Tau421 亚 型 IgG 纯化方法 affinity purified by Protein A 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 产品介绍 Tau421 promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C terminus binds axonal microtubules while the N terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. There are nine named isoforms. Subcellular Location : Cytoplasm, cytosol, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.