Product overview
Description Anti-PVR rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Fusion protein of human PVR
Reactivity Human
Content 0.1 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol PVR
Full name poliovirus receptor
Synonyms PVS; HVED; CD155; NECL5; TAGE4; Necl-5
Swissprot P15151
Target Background
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.